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Atypical Neuroleptics

The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called ”atypical” neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intra- and interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required.

The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, which allows a direct sample injection into the HPLC system.

Sample Pretreatment


Sample Preparation Atypical Neuroleptics online Plasma Serum

Chromatography


Chromatogram Atypical Neuroleptics online Plasma Serum

Ordering Information


Order No.


Description


Quantity


40000


ClinRep® Complete Kit for Atypical Neuroleptics in Plasma / Serum for 100 assays


1 pce.


Kit Components (order no. 40000):


40009


SPE-Buffer


2 x 40009 (2 x 1000 ml)


40010


Mobile Phase


2 x 40010 (2 x 2000 ml)


40013


Plasma Calibrator, lyophil.


5 x 3 ml


Manual


1 pce.


Quick Reference


1 pce.


Optional Components:


40012


Internal Standard IS


2 ml


40014


Test Solution, lyophil.


5 x 2 ml


40113


Plasma Calibrator, lyophil., for Risperidone and Paliperidone


5 x 5 ml


40114


Test Solution, for Risperidone and Paliperidone


15 ml


Start Accessories:


40030


Analytical Column with test chromatogram


1 pce.


40031


SPE-Column


1 pce.


40032


Guard Column Holder incl. 1 Guard Column


1 pce.


40033


Guard Column


5 pcs.


FK7400


Inline-Filter (stainless steel sieve, free of dead volume)


1 pce.


Refill Service:


40034


SPE-Column, refill (original column needs to be returned)


1 pce.


Accessories:


FK1102


Switching valve, Sykam (6-port/3-channel) incl. electr. drive, PEEK


1 pce.


FK7340


Sealings and sieves


4 pcs. each


ClinChek® Controls:


40080


Plasma Control, lyophil., Level I


10 x 3 ml


40081


Plasma Control, lyophil., Level II


10 x 3 ml


40082


Plasma Control, lyophil., Level I, II


2 x 5 x 3 ml


40180


Plasma Control, lyophil., for Risperidone and Paliperidone, Level I


10 x 5 ml


40181


Plasma Control, lyophil., for Risperidone and Paliperidone, Level II


10 x 5 ml


40182


Plasma Control, lyophil., for Risperidone and Paliperidone, Level I, II


2 x 5 x 5 ml



Download product brochures, product documents (e.g. safety data sheets), and instructions for use.

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