Atypical Neuroleptics

The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called ”atypical” neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required.

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