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Methylmalonic Acid, advanced

Methylmalonic acid (MMA) serves for the assessment of the vitamin B12 status. Vitamin B12 deficiency leads to an increased MMA concentration in serum, plasma and urine.

The RECIPE ClinMass® Complete Kit provides a fast MMA analysis featuring short sample preparation with only one pipetting step (serum, plasma) or direct injection of samples after dilution and addition of IS (urine). The subsequent LC-MS/MS analysis is performed within a 2 min injection interval only while the isobar component succinic acid, which may interfere with MMA, is reliably separated. The method is fully validated using only one (serum) calibration and control set for all three sample matrices (ClinCal® 4-Level Calibrator Set and ClinChek® Controls).

Sample Preparation


Sample Preparation Methylmalonic Acid advanced Plasma Serum Urine

Chromatography


Chromatogram Methylmalonic Acid advanced Plasma Serum Urine

Ordering Information


Order No.


Description


Quantity


MS5100


ClinMass® Complete Kit, advanced, for Methylmalonic Acid in Serum / Plasma / Urine


for 300 assays


1 pce.


Kit Components (order no. MS5100):


MS5005


Autosampler Washing Solution


1000 ml


MS5108


Mobile Phase A


1000 ml


MS5109


Mobile Phase B


200 ml


MS5112


Precipitant P with Internal Standard


3 x MS5112 (3 x 40 ml)


MS5013


Serum Calibrator Set, lyophil., (Level 0 – 3)


4 x 1 x 2 ml


MS5020


Sample Preparation Vials


3 x MS5020 (3 x 100 pcs.)


Manual


1 pce.


Additional Components:


MS5114


Optimisation Mix


2 ml


MS5021


Diluting Solution D for Urine


50 ml


Start Accessories:


MS5130


Analytical Column with test chromatogram


1 pce.


ClinChek® Controls:


MS5080


Serum Control, lyophil., Level I


10 x 2 ml


MS5081


Serum Control, lyophil., Level II


10 x 2 ml


MS5082


Serum Control, lyophil., Level I, II


2 x 5 x 2 ml



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